Synthesis and PKC Binding of a New Class of A-Ring Diversifiable Bryostatin Analogues Utilizing a Double Asymmetric Hydrogenation and Cross-Coupling Strategy
โ Scribed by Wender, Paul A.; Horan, Joshua C.
- Book ID
- 127190538
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 100 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1523-7060
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The synthesis and biological assay of a new series of designed bryostatin analogues modiยฎed at the C20 position are described. These compounds are found to bind to protein kinase C with anities of up to 1.5 nM, demonstrating that variations at C20 can indeed be used to tune anity and potentially fun