Synthesis and Physicochemical Characterization of Cyclic Laminin Related Peptides
✍ Scribed by Fernández, A.; Alsina, M A.; Haro, I.; Galantai, R.; Reig, F.
- Book ID
- 125900593
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 109 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0743-7463
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The synthesis of hydrophobic peptide derivatives related to the laminin sequence [YIGSR NH 2 ] is described. Hydrophobicity is achieved by the attachment of decanoic, myristic, or stearic acids to the amino terminal end of the peptide. Moreover, a cholesterol residue was also introduced as succinimi
## Abstract The synthesis is described of several peptides containing the sequence Phe‐Met. In order to limit enzymatic degradation and to restrict the number of possible conformations they were cyclized with variable ring size. Some unexpected side‐reactions were encountered during the synthesis o