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Synthesis and Physicochemical Characterization of a New Gadolinium Chelate: The Liver-Specific Magnetic Resonance Imaging Contrast Agent Gd-EOB-DTPA

✍ Scribed by Schmitt-Willich, H.; Brehm, M.; Ewers, Ch. L. J.; Michl, G.; Müller-Fahrnow, A.; Petrov, O.; Platzek, J.; Radüchel, B.; Sülzle, D.


Book ID
126792553
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
145 KB
Volume
38
Category
Article
ISSN
0020-1669

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✍ Gabriele Schuhmann-Giampieri; Heribert Schitt-Willich; Thomas Frenzel 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 735 KB

The introduction of a lipophilic moiety into the gadolinium chelate Gd-DTPA (dimeglumine gadopentetate, Magnevist) yielded Gd-EOB-DTPA (short form), which has potential as a magnetic resonance contrast agent for liver mass screening. The pharmacokinetics of Gd-EOB-DTPA in rats is nonlinear because a