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Synthesis and Phenotypic Screening of a Guanine-Mimetic Library

✍ Scribed by Stephen C. Miller; Timothy J. Mitchison

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
109 KB
Volume
5
Category
Article
ISSN
1439-4227

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The solid-phase synthesis of a dipeptide derived 2-amino-3-oxohexahydroindolizino[8,7-b]indole-5-carboxylate system (IBTM) is described. The IBTM moiety is formed via a solid-phase mediated Pictet-Spengler reaction of N-terminal tryptophan and the 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-me