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Synthesis and Pharmacophore Modeling of Naphthoquinone Derivatives with Cytotoxic Activity in Human Promyelocytic Leukemia HL-60 Cell Line

✍ Scribed by Pérez-Sacau, Elisa; Díaz-Peñate, Raquel G.; Estévez-Braun, Ana; Ravelo, Angel G.; García-Castellano, Jose M.; Pardo, Leonardo; Campillo, Mercedes

Book ID
120803347
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
401 KB
Volume
50
Category
Article
ISSN
0022-2623

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✍ P. H. Naccache; T. F. P. Molski; B. Spinelli; P. Borgeat; C. N. Abboud 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 595 KB

## Abstract We have begun to characterize the development of the excitation – response coupling sequence in the human promyelocytic leukemia cell line HL60. Using the recently developed fluorescent calcium probe quin‐2, it was found that DMSO induced myeloid differentiation of the HL60 cells is acc