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Synthesis and Pharmacological Evaluation of Prenylated and Benzylated Pterocarpans Against Snake Venom.

✍ Scribed by Alcides J. M. da Silva; Antonio L. Coelho; Alessandro B. C. Simas; Raphael A. M. Moraes; Diogo A. Pinheiro; Fabricio F. A. Fernandes; Emerson Z. Arruda; Paulo R. R. Costa; Paulo A. Melo

Publisher
John Wiley and Sons
Year
2004
Weight
124 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract Both enantiomers of 2‐benzyl‐5‐bromo‐4‐oxopentanoic acid were prepared utilizing the diazo ketones as the key intermediates. The compounds were assayed for inhibitory activity against carboxypeptidase A (CPA, EC 3.4.17.1). The (__R__)‐form is 260‐fold more potent than the corresponding