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Synthesis and pharmacological evaluation of highly potent dual histamine H2 and gastrin receptor antagonists

โœ Scribed by Yasuyuki Kawanishi; Shoichi Ishihara; Tadahiko Tsushima; Kaoru Seno; Masanori Miyagoshi; Sanji Hagishita; Michio Ishikawa; Noriko Shima; Mayumi Shimamura; Yasunobu Ishihara


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
260 KB
Volume
6
Category
Article
ISSN
0960-894X

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๐Ÿ“œ SIMILAR VOLUMES


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โœ Yasuyuki Kawanishi; Shoichi Ishihara; Tadahiko Tsushima; Kaoru Seno; Masanori Mi ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 436 KB

The joint type of hybrid molecules composed of two pharmacophore moieties taken from histamine H2 and gastrin receptor antagonists have been designed and synthesized to exhibit dual histamine H2 and gastrin receptor antagonistic activities. Here we report the importance of spacers as well as binding

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