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Synthesis and pharmacological evaluation of a novel series of 5-aryl benzimidazole angiotensin II receptor antagonists

โœ Scribed by Alan D. Palkowitz; Mitchell I. Steinberg; Karen M. Zimmerman; K.Jeff Thrasher; Kenneth L. Hauser; Donald B. Boyd


Book ID
103982928
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
249 KB
Volume
5
Category
Article
ISSN
0960-894X

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Synthesis and pharmacological evaluation
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A series of novel aryl aminosulfonamides was designed and synthesized as 5-HT 6 receptor ligands. Many compounds screened in a functional reporter gene based assay displayed potent antagonistic activity with Kb values in the range of 0.02-10 nM. The lead compound 11m exemplified in this series showe