Synthesis and pharmacological characterization of A-80426: A putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition

✍ Scribed by Michael D. Meyer; Arthur A. Hancock; Karin Tietje; kevin B. Sippy; William J. Giardina; James F. Kerwin Jr.

• Book ID: 103983099
• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 289 KB
• Volume: 5
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(95)00398-d

✦ Synopsis

ethyl]-N-[(R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-ylmethyl]-N-methylamine) represents the first example of a new structural class of agents combining potent c~-2 antagonist activity with equivalent 5-HT uptake inhibitory activity. This profile of combined activities may have utility in the treatment of depression.

Modulation of biogenic amines, particularly serotonin and norepinephrine, is the principal pharmacological mechanism of action of all therapeutic agents currently in use for the treatment of depressive disorders. 2 Inhibitors of norepinephrine (NE) or serotonin (5-HT) reuptake are currently among the most efficacious