Synthesis and pharmacological characterization of (.+-.)-5,9.alpha.-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo

Synthesis of a radiotracer for studying

Synthesis of a radiotracer for studying σ receptors in vivo using PET: (+)-N-[11C]-benzyl-N-normetazocine (1S, 5S,9S-(+)-cis-2-[11C]-2′-hydroxy-5,9-dimethyl-6,7-benzomorphan)

✍ John L. Musachio; William B. Mathews; Hayden T. Ravert; F. Ivy Carroll; Robert F 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 440 KB

## Abstract (+)‐__N__‐[^11^C]‐Benzyl‐__N__‐normetazocine (1__S__,5__S__,9__S__‐(+)‐__cis__‐2‐[^11^C]‐benzyl‐2′‐hydroxy‐5,9‐dimethyl‐6,7‐benzomorphan), a potent and selective ligand for the σ receptor, was prepared by N‐benzylation of (+)‐__cis__‐__N__‐normetazocine with [α‐^11^C]‐benzyl iodide in e