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Synthesis and pharmacological characterization of 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid and 5-[2-(8-phenyloctyl)phenyl]-4,6-dithianonanedioic acid: prototypes of a novel class of leukotriene antagonists

โœ Scribed by Perchonock, Carl D.; McCarthy, Mary E.; Erhard, Karl F.; Gleason, John G.; Wasserman, Martin A.; Muccitelli, Roseanna M.; DeVan, Jeris F.; Tucker, Stephanie S.; Vickery, Lynne M.


Book ID
126111241
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
305 KB
Volume
28
Category
Article
ISSN
0022-2623

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Two lqC-labelled leukotriene receptor antagonists were prepared from two aryl bromides and potassium [ 14C]cyanide. cyanide was converted to copper(1) [L4C]cyanide and was subsequently used to displace the bromine atom from two dry1 bromides, 2-dodecylbromobenzene and 2-(8-phenyloctyl)bromobenzene.