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Synthesis and pharmacological activity of new N,N′,N″-substituted guanidines

✍ Scribed by R. G. Glushkov; L. N. Dronova; L. A. Nikolaeva; B. A. Medvedev; M. D. Mashkovskii; N. P. Solov'eva; K. F. Turchin; I. V. Persianova


Book ID
112408187
Publisher
Springer
Year
1978
Tongue
English
Weight
463 KB
Volume
12
Category
Article
ISSN
0091-150X

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Solid-phase synthesis of N,N′ substitute
✍ Dharmpal S. Dodd; Owen B. Wallace 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 201 KB

An efficient method for the solid-phase synthesis of substituted guanidines is presented. A variety of alcohols react with resin-bound N,N'-bis(t-butoxycarbonyl)thiopseudourea under Mitsunobu conditions to give the corresponding alkylated thiopseudoureas. The guanidines are liberated from the resin