Oxidation of the 22-hydrazone of ascomycin using manganese dioxide generates in situ the reactive 22-diazo intermediate, which decomposes to give ascomycin analogues with modified effector region. In dichloromethane several products are obtained, whereas in methanol a cyclopropane derivative is gene
β¦ LIBER β¦
Synthesis and oxidative cleavage of the major equilibrium products of ascomycin and FK 506
β Scribed by K Baumann; B Oberhauser; M.A Grassberger; G Haidl; G Schulz
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 205 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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