✦ LIBER ✦

Synthesis and opioid binding properties of 2-chloroacrylamido derivatives of 7,8-dihydromorphinans

✍ Scribed by Ian Hutchinson; Sydney Archer; Kevin P. Hill; Jean M. Bidlack

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 158 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00274-0

No coin nor oath required. For personal study only.

✦ Synopsis

2-chloroacrylamido-7,8-dihydromorphinones 7 and 8 and the corresponding 61]-7,8-dihydromorphinans 19 and 20 were prepared and the binding affinities to It, $ and K receptors in bovine striatal membranes were determined. Only 20 produced wash-resistant inhib ition of m binding despite the fact that it formed adducts with N-acetylcysteine at pH 10 and not at pH 8.

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