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Synthesis and Odor Properties of Substituted Indane-2-carboxaldehydes. Discovery of a New Floral (Muguet) Fragrance Alcohol

✍ Scribed by Béat Winter; Sandrine Gallo-Flückiger


Publisher
John Wiley and Sons
Year
2005
Tongue
German
Weight
135 KB
Volume
88
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

Eight substituted indane‐2‐carboxaldehydes (= 2,3‐dihydro‐1__H__‐indene‐2‐carboxaldehydes), related to conformationally constrained analogues of floral‐type odorants, were synthesized in order to examine the effect of modifying the lipophilic part of the odorants (Schemes 1 and 2). None of the modified compounds showed better olfactive properties than the original ones (Tables 1 and 2), but an intermediate alcohol, 29, revealed itself as a valuable new member in the family of floral muguet (lily‐of‐the‐valley)‐type odorants.