✦ LIBER ✦

Synthesis and nonthrombogenicity of polymer membrane with surface-graft polymers carrying thrombin inhibitor

✍ Scribed by Ito, Yoshihiro ;Liu, Lin-Shu ;Matsuo, Ryuichi ;Imanishi, Yukio

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 775 KB
Volume: 26
Category: Article
ISSN: 0021-9304
DOI: 10.1002/jbm.820260808

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✦ Synopsis

An acrylamide derivative of a thrombin inhibitor was synthesized and graft polymerized to the surfaces of polymer membranes. The thrombin-inhibitor activity was unaffected by the introduction of an acryloyl group. The surface-graft membrane deactivated thrombin markedly and suppressed adhesion of platelets, result-ing in a high nonthrombogenicity. Immersion of polymer membranes blended with the thrombin inhibitor in phosphatebuffered saline for 10 d resulted in the loss of nonthrombogenicity, while the polymer membranes grafted with the thrombin inhibitor derivative maintained the nonthrombogenicity over a long period.

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