## Abstract The two diastereomers of spirocyclic 5,6‐dimethyl‐4H‐1,3‐dioxin‐4‐one (5, 6) have been synthesized by acetalization of tert‐butyl 2‐methyl‐3‐oxobutanoate (2) with (−)‐menthone (4). Their structures have been determined by NMR analysis.
Synthesis and NMR configurational analysis of 1,3-imidazolidin-4-ones derived from (−)-(S)-phenylethylamine
✍ Scribed by Cirilo García-Martínez; Humberto Cervantes-Cuevas; Jaime Escalante-Garcia
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 237 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0899-0042
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The reactions of methyl glyoxylate hemiacetal 1 with 2-(methy1amino)ethanol 2, ( I R,2S)-( -)-ephedrine 3 and (IS,2S)-( +) -pseudoephedrine 4 provide the (2s)-2-hydroxy-l,4-oxazin-3-ones 2% 3% 4a i n good yield. They were characterized by 'H, I3C, NMR, and infrared and mass spectroscopy. The structu
## Abstract The ^1^H and ^13^C NMR spectra of 26 2,3‐dihydro‐[1,5]benzoxazepin‐4(5__H__)‐one derivatives and four thiono analogues are interpreted in terms of conformational equilibria. Similar to 1,3,4,5‐tetrahydro‐2__H__‐1,5‐benzodiazepin‐2‐ones, these compounds favour boat conformations of the s