Synthesis and NMR Characterization of New Hyaluronan-Based NO Donors
β Scribed by Di Meo, Chiara; Capitani, Donatella; Mannina, Luisa; Brancaleoni, Enzo; Galesso, Devis; De Luca, Gilda; Crescenzi, Vittorio
- Book ID
- 127356031
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 155 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1525-7797
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## Abstract Several new biocompatible and degradable materials were prepared by chemical modification of sodium hyaluronate. The method of activation of hyaluronate by cyanogen bromide was used and subsequent reaction with nucleophile led to the formation of carbamate. This modification of hydroxyl
Partial chemical deacetylation of hyaluronan (HA) has been carried out using known procedures and carefully controlled experimental conditions in order to minimize chain degradation. The sample described herein (deHA) has a degree of deacetylation of about 17%, which corresponds to what required for