Synthesis and Neuroprotective Properties of Isosteric Analogs of Nicotine
✍ Scribed by E. D. Matveeva; T. A. Podrugina; I. G. Morozkin; S. E. Tkachenko; N. S. Zefirov
- Book ID
- 111527716
- Publisher
- Springer US
- Year
- 2000
- Tongue
- English
- Weight
- 112 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0009-3122
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## Abstract A synthetic approach leading to novel‐type modified oligothymidylates containing an isosteric, isopolar, enzyme‐stable __C3__′__‐O‐P‐CH~2~‐O‐C4__″ phosphonate alternative to phosphodiester internucleotide bond was elaborated. The suitable monomers were prepared from 4′‐phosphonomethoxy
Four 1251-labelled nicotine analogs were synthesized: 3-(methylpropylaminomethyl)-, 3-(diethylaminomethyl)-, 3-(isopropylaminomethy1)-, and 3-(diisopropylaminomethy1)-5-[ 1251]-iodopyridines. 5-Bromonicotinic acid was acylated with thionyl chloride and then reacted with the appropriate primary and s