Synthesis and modelling of DNA junction and minor groove zipper motifs incorporating the double-headed nucleoside 5?(S)?C-(thymine-1-ylmethyl)thymidine

Synthesis and Molecular Modelling of Dou

Synthesis and Molecular Modelling of Double-Functionalised Nucleosides with Aromatic Moieties in the 5′-(S)-Position and Minor Groove Interactions in DNA Zipper Structures

✍ Dr. Khalil Isak Shaikh; Charlotte Stahl Madsen; Lise Junker Nielsen; Anna Sønder 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 805 KB

## Abstract A series of six double‐functionalised nucleosides, in which aromatic moieties were inserted into the 5′‐(__S__)‐__C__‐position, were synthesised and incorporated into DNA duplexes. The aromatic moieties were thymine‐1‐yl, phenyl, 1,2,3‐triazol‐1‐yl, 1,2,3‐triazol‐4‐yl, 4‐(uracil‐5‐yl)‐1