Synthesis and microbial evaluation of novelN(1)-Arilidene-N(2)-t(3)-methyl-r(2),c(6)-diaryl-piperidin-4-one azine derivatives
β Scribed by J. Jayabharathi; A. Thangamani; M. Padmavathy; B. Krishnakumar
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 225 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1054-2523
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## Abstract Thiosemicarbazones are having the ability to bind with metal and inhibit the enzyme ribonucleoside diphosphate reductase (RDR), an enzyme which is involved in the synthesis of DNA precursors in the mammalian cells. The title compound Nβmethylβtβ3βmethylβrβ2, cβ6βdiphenylpiperidinβ4βone
An investigation of the kinetics of oxidation of epimeric piperidin-4-ols, oxan-4-ols, and cyclohexanol by N-chloro-r-2, c-6-diphenyl-t-3-methylpiperidin-4-one (NCP) in aqueous acetic acid in the presence of perchloric acid shows that the reaction is first-order each in substrate and oxidant. Both H