Synthesis and Metalation of Novel Fluorescent Conjugated Macrocycles
β Scribed by Ma, Cecily; Lo, Andy; Abdolmaleki, Amir; MacLachlan, Mark J.
- Book ID
- 120416774
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 149 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1523-7060
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## Abstract A novel folate fluorescent nanoconjugate was synthesized and used for detection of cancer cells overexpressing the folate receptor (FR). The folate conjugate (PCMSβNAβFA) was synthesized by conjugating folic acid (FA) and 4βethylnylβ__N__βethylβ1, 8βnaphthalimide (NA) to the polychlorom
H N M R spectrum even in [D,]DMSO as a solvent. since the N -H signals of the free and complexed 3 appear at 6 = 10.47 and 11.21. respectively. Complexation of Kions by receptor 3 was studied by picrate (Pic) extraction[\*] experiments. For the 1 : 1 complex 3 K'Pica value of Ig K,, = 5.3 was obtai