Synthesis and metabolism of roquefortine in Penicillium species

✍ Scribed by Dr. Tatiana A. Reshetilova; Anatoly G. Kozlovsky

• Book ID: 102393911
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 367 KB
• Volume: 30
• Category: Article
• ISSN: 0233-111X
• DOI: 10.1002/jobm.3620300213

✦ Synopsis

The uptake of exogeneous '4C-roquefortine by Penicillium furinosum cells and its metabolism was followed. Growth and roquefortine biosynthesis of three Penicillium species during a cultivation period of 14 d were investigated. Furthermore. the effect of cultivation conditions viz. various culture media on roquefortine uptake and biosynthesis as well as biomassproduction were studied. Some general problems of physiology and metabolic regulation of alkaloid formation in Penicillium species were discussed. Roquefortine (Fig. 1) is a diketopiperazine alkaloid-having neurotrophic (SCOTT et al. (KAFJP and REHM 1979) activities. It was first found in the fungus Penicillium roqueforti as the major component of the alkaloid fraction (OHMOMO et al.

1976. and antibiotic