Synthesis and metabolic fate of purine nucleotides in cultured fibroblasts from normal subjects and from purine overproducing mutants
โ Scribed by Esther Zoref; Osnat Sivan; Oded Sperling
- Book ID
- 115747073
- Publisher
- Elsevier Science
- Year
- 1978
- Weight
- 438 KB
- Volume
- 521
- Category
- Article
- ISSN
- 0005-2787
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Human lymphoblasts derived from normal and hypoxanthine-guanine phos-phoribosyItransferase (HGPRT) deficient individuals have been maintained in permanent tissue culture, and comparative studies of their purine metabolism have been undertaken. In agreement with previous observations in fibroblasts,
## Abstract Cultured skin fibroblasts from a patient with Tโcell immune deficiency and an absence of purine nucleoside phosphorylase activity in red cells were assayed for their capacity to metabolize inosine and guanosine. The cultured fibroblasts were lacking activity of nucleoside phosphorylase