𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and melanotropic activity of γ-melanotropin

✍ Scribed by W. A. A. J. Bijl; J. W. van Nispen; H. M. Greven

Book ID
104588312
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
485 KB
Volume
100
Category
Article
ISSN
0165-0513

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

γ‐MSH, a third melanotropic sequence in the N‐terminal cryptic portion of the ACTH/β‐LPH precursor molecule pro‐opiocortin, was synthesized by the fragment condensation approach. The dodecapeptide H‐Tyr‐Val‐Met‐Gly‐His‐Phe‐Arg‐Trp‐Asp‐Arg‐Phe‐Gly‐OH was tested for melanocyte‐stimulating activity on the skin of the lizard Anolis Carolinensis and was found to possess only 2.5 × 10^−4^ of the activity of α‐MSH.

📜 SIMILAR VOLUMES

Melanotropin Receptors II. Synthesis and
Melanotropin Receptors II. Synthesis and Biological Activity of α-Melanotropin/Tobacco Mosaic Virus Disulfide Conjugates
✍ Rudolf Wunderlin; Shub Dev Sharma; Panagiota Minakakis; Robert Schwyzer 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 German ⚖ 683 KB

## Abstract Asymmetric disulfide conjugates of mercaptosuccinyl tobacco mosaic virus (TMV ∼ SH) with __N__^α^‐desacetyl‐__N__^α^‐5‐(mercaptovaleryl)‐α‐melanotropin were prepared __via__ the __S__‐sulfoderivative of the peptide. The conjugates, TMV ∼ SS ∼ α‐MSH(__n__), contained up to __n__ = 330 d

Melanotropin Receptors I. Synthesis and
Melanotropin Receptors I. Synthesis and Biological Activity of Nα-(5-Bromovaleryl)-Nα-deacetyl-α-melanotropin
✍ Rudolf Wunderlin; Panagiota Minakakis; Aung Tun-Kyi; Shub Dev Sharma; Robert Sch 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 German ⚖ 699 KB

## Abstract Chemical synthesis and biological activities of a new α‐melanotropin derivative are described. __N__^α^‐(5‐Bromovaleryl)‐__N__^α^‐deacetyl‐α‐melanotropin contains the 5‐bromopentanoyl group as a chemical ‘handle’ in place of the acetyl group of the natural hormone. The synthesis involve