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Synthesis and lipase-mediated stereoselective deacetylation of (±)-3-acetoxymethyl-3-alkyl-7-methoxychroman-4-ones

✍ Scribed by Poonam; Ashok K Prasad; Abul Azim; Rajesh Kumar; Subhash C Jain; Virinder S Parmar; Carl E Olsen; William Errington


Book ID
108371321
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
160 KB
Volume
57
Category
Article
ISSN
0040-4020

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Quaternary a-amino acids a b s t r a c t Chiral symmetrical alk-2-yne-1,4-diols have been stereoselectively transformed into 5-alkyl-4-alkenyl-4phenyl-1,3-oxazolidin-2-ones, which are precursors of quaternary a-amino b-hydroxy acids. The key step was the cyclization of the bis(tosylcarbamates) of 2-