𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and labelling characteristics of 99mTc-mercaptoacetyltripeptides

✍ Scribed by G. Bormans; B. Cleynhens; P. Adriaens; M. de Roo; Prof. Dr. A. Verbruggen

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
700 KB
Volume
33
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A number of derivatives of mercaptoacetyltriglycine in which one or more of the three glycylmoieties are replaced by other amino acids such as D‐ or L‐alanine, D‐serine, D‐2‐aminobutyric acid, D‐valine or D‐phenylglycine have been synthesized and labelled with technetium‐99m.

Labelling with technetium yielded in each a mixture of mainly two radioactive species, which probably are diastereomeric oxotechnetium (V) complexes originating from the presence of a chiral carbon atom in the ligands. The diastereomers were separated by reversed phase HPLC. Except for the serine derivative, all radiolabelled derivatives have a longer retention time than the parent compound ^99m^Tc‐MAG~3~. The relative amount of the two diastereomers formed upon labelling is dependent on the nature of the ligand but can be influenced to a limited extent by the pH of the exchange labelling mixture.

📜 SIMILAR VOLUMES

Labelling of fly ash with 99mTc
Labelling of fly ash with 99mTc
✍ P.C. Crossley; D.J. Spedding; P.L. Spedding; R. Woulfe 📂 Article 📅 1977 🏛 Elsevier Science ⚖ 329 KB
On the 99mTc-labeling of isoniazid with
On the 99mTc-labeling of isoniazid with different 99mTc cores
✍ Grace Samuel; Kanchan Kothari; Sharmila Banerjee; Tapas Das; Suresh Subramanian; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 174 KB

Recent advances in the chemistry of radiolabeling with 99m Tc such as use of the 99m Tc tricarbonyl and 99m Tc-HYNIC cores have revived interest in 99m Tc-labeling of small biomolecules and further investigation as potential radiopharmaceuticals. Isoniazid, a drug commonly used for treatment of tube

Synthesis and radiobiological evaluation
Synthesis and radiobiological evaluation of a new 99mTc-labeled small peptide: 99mTc-YGGSLAK as imaging agent
✍ Kakali De; Susmita Chandra; Santanu Ganguly; Bhart Sarkar; Mridula Misra 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 375 KB

## Abstract Peptides are known as receptor‐specific molecules that play an important role not only in diagnosis and therapy of neoplastic diseases, but also in the pathogenesis of other diseases. In an effort to develop a peptide‐based radiopharmaceutical for scintigraphic studies, a small peptide