Synthesis and kinetic cyclisation of quinine-derived oligomers
โ Scribed by Stuart J Rowan; Paul A Brady; Jeremy K.M Sanders
- Book ID
- 103412986
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 225 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The vinyl radicals 2a, 2b, and 11 each undergo fast exe ring closure to give 5a, 5b, and 12, the first two of which readily rearrange to ring-expanded radicals.
Quinine and quinidine were synthesized by a highly enantio-and stereoselective approach starting from a proline-catalyzed asymmetric cycloaldolization of benzyl bis(2-formylethyl)carbamate which gave a 70:30 mixture of (3R,4R)-N-Cbz-3-hydroxymethyl-4-hydroxypiperidine (96% ee) and its 4S-epimer (92%
Human fibrinogen was treated with thrombin in the presence of fibrinoligase (Factor XIIIa) and calcium ion at pH 8.5, ionic strength 0.45, and the ensuing polymerization was interrupted at various time intervals ( t ) both before and after the clotting time (t,) by solubilization with a solution of