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Synthesis and Inhibitory Activities against Enkephalin Degrading Aminopeptidase of H-Trp(Nps)-Lys-OMe Analogues Bearing Chelating Groups

✍ Scribed by Rosario Gonzalez-Muniz; Juan R. Harto; Maria L. De Ceballos; Joaquin Del Rio; M. Teresa Garcia-López

Book ID: 102750132
Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 604 KB
Volume: 325
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.19923251202

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In order to determine the influence of the N-terminal amino group of the dipeptide derivatives H-Xaa-Trp@ps)-OMe[Xaa=Lys (2a). Om (2b). Arg ( 2 4 on their antinociceptive effects, the syntheses of their cmponding deaminated. acetylated and dimethylated analogues have been achieved. Deamino and dime