## Abstract The tropane alkaloid RTI‐82, an iodoarylazide, has been labeled with iodine‐125 for use as a photoaffinity probe for the cocaine binding site of the dopamine transporter. The one‐flask radiosynthesis involves nocarrier‐added electrophilic radioiodination of the corresponding aniline fol
✦ LIBER ✦
Synthesis and in vivo studies of a selective ligand for the dopamine transporter: 3β-(4-[125I]iodophenyl) tropan-2β-carboxylic acid isopropyl ester ([125I]RTM-21)
✍ Scribed by John R. Lever; Ursula Scheffel; Marigo Stathis; Herbert H. Seltzman; Christopher D. Wyrick; Philip Abraham; Karol Parham; Brian F. Thomas; John W. Boja; Michael J. Kuhar; F.Ivy Carroll
- Book ID
- 116172111
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 944 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0969-8051
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The present study describes the binding of cocaine analog [ 125 I]3b-(iodophenyl)tropan-2b-carboxylic acid isopropyl ester ([ 125 I]RTI-121), a highly selective ligand for the dopamine transporter (DAT), to rat striatal synaptosomal membranes at 37°C. Saturation analysis of [ 125 I]RTI-121 binding r