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Synthesis and in vivo evaluation of a novel hydroxyapatite/collagen–alginate as a bone filler and a drug delivery carrier of bone morphogenetic protein

✍ Scribed by Shinichi Sotome; Toshimasa Uemura; Masanori Kikuchi; Jiani Chen; Soichiro Itoh; Junzo Tanaka; Tetsuya Tateishi; Kenichi Shinomiya

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
585 KB
Volume
24
Category
Article
ISSN
0928-4931

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## Abstract A hydroxyapatite/collagen (HAC) composite was produced to mimic the natural extracellular matrix of bone, with the collagen serving as a template for apatite formation. A three‐dimensional highly porous scaffold was developed by mixing HAC with poly(L‐lactic acid) (PLA) using a thermall