✦ LIBER ✦
Synthesis and in vitro Evaluation of 4-(2-Glyceryl)butyric Acid: A Glyceride Mimic for Drug Delivery via Drug-Lipid Conjugates. Synthese und in vitro Charakterisierung der 4-(2-Glyceryl)buttersäure: Ein Glyceridanalogon für “Drug Delivery” mittels Arzneistoff-Lipid Konjugaten
✍ Scribed by Gerhard K. E. Scriba
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 226 KB
- Volume
- 327
- Category
- Article
- ISSN
- 0365-6233
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✦ Synopsis
There has been some evidence that mixed triglycerides formed from coupling of drugs to diglycerides exhibit physicochemical and absorption as natural Wiglycerides. Drugs which lack carboxyl groups, allowing the direct formation of an ester bond with a diglyceride, can be bound via spacers such as succinic acid. However, these lipids may undergo acyl migration of the succinate residue during lipolysis, a phenomenon also observed during the digestion of natural triglycerides especially for shorter-chain acid residues5). The resulting mono succinic acid esters are poor substrates for hydrolytic enzymes').