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Synthesis and in vitro biological evaluation of nitric oxide-releasing derivatives of hydroxylcinnamic acids as anti-tumor agents

โœ Scribed by Lu, Ming-Dong; Zhou, Xiao; Yu, Yao-Jun; Li, Pi-Hong; Sun, Wei-Jian; Zhao, Cheng-Guang; Zheng, Zhi-Qiang; You, Tao; Wang, Fei-Hai


Book ID
123110751
Publisher
Chinese Electronic Periodical Services
Year
2013
Tongue
English
Weight
363 KB
Volume
24
Category
Article
ISSN
1001-8417

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A series of novel furoxan-based nitric oxide (NO)-releasing derivatives of glycyrrhetinic acid (GA) were designed, synthesized, and evaluated for their in vitro cytotoxicity against human hepatocellular carcinoma (HCC) and non-tumor liver cells. Five furoxan/GA hybrids, 7b-d, 7f, and 7g, displayed p