✦ LIBER ✦

Synthesis and in vitro biological evaluation of new triphenylethylene platinum (II) complexes

✍ Scribed by Yuehua He; Serge Groleau; RenéC. -Gaudreault; Madeleine Caron; Hélène-M. Thérien; Gervais Bérubé

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 306 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00381-3

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✦ Synopsis

In our search for a chemotherapeutic agent with a better therapeutic index and selectivity for the treatment of breast cancer, we have synthesized cytotoxic triphenylethylene derivatives. The synthesis of this type of compound is straightforward and efficient. The biological activity of these compounds was evaluated in vitro on ER+ and ER-human breast tumor cell lines: MCF-7 and MDA-MB-231.

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