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Synthesis and in Vitro and in Vivo Activity of (−)-(1 R ,5 R ,9 R )- and (+)-(1 S ,5 S ,9 S )- N -Alkenyl-, - N -Alkynyl-, and - N -Cyanoalkyl-5,9-dimethyl-2‘-hydroxy-6,7-benzomorphan Homologues

✍ Scribed by May, Everette L.; Jacobson, Arthur E.; Mattson, Mariena V.; Traynor, John R.; Woods, James H.; Harris, Louis S.; Bowman, Edward R.; Aceto, Mario D.


Book ID
120802696
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
69 KB
Volume
43
Category
Article
ISSN
0022-2623

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## Abstract (+)‐__N__‐[^11^C]‐Benzyl‐__N__‐normetazocine (1__S__,5__S__,9__S__‐(+)‐__cis__‐2‐[^11^C]‐benzyl‐2′‐hydroxy‐5,9‐dimethyl‐6,7‐benzomorphan), a potent and selective ligand for the σ receptor, was prepared by N‐benzylation of (+)‐__cis__‐__N__‐normetazocine with [α‐^11^C]‐benzyl iodide in e