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Synthesis and in vitro analysis of atrial natriuretic peptide–albumin conjugates

✍ Scribed by Roger Léger; Martin Robitaille; Omar Quraishi; Elizabeth Denholm; Corinne Benquet; Julie Carette; Pieter van Wyk; Isabelle Pellerin; Nathalie Bousquet-Gagnon; Jean-Paul Castaigne; Dominique Bridon

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
343 KB
Volume
13
Category
Article
ISSN
0960-894X

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✦ Synopsis

Atrial natriuretic peptide (ANP) is a clinically useful anti-hypertensive hormone. Maleimide derivatives of ANP have been synthesized and conjugated to cysteine-34 of human serum albumin. The conjugates were analyzed to assess their stability, receptor binding affinity and ability to stimulate guanylyl-cyclase activity in rat lung fibroblasts.

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