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Synthesis and in Vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones: Allosteric Modulators of the GABA A Receptor †

✍ Scribed by Hogenkamp, Derk J.; Tahir, S. Hasan; Hawkinson, Jon E.; Upasani, Ravi B.; Alauddin, Mian; Kimbrough, Catherine L.; Acosta-Burruel, Manuel; Whittemore, E. R.; Woodward, R. M.; Lan, Nancy C.; Gee, Kelvin W.; Bolger, Michael B.


Book ID
126424855
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
444 KB
Volume
40
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Synthesis and in vi
✍ D. J. HOGENKAMP; S. H. TAHIR; J. E. HAWKINSON; R. B. UPASANI; M. ALAUDDIN; C. L. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

Synthesis and in vitro Activity of 3β-Substituted-3α-hydroxypregnan-20-ones: Allosteric Modulators of the GABAA Receptor. -A series of 3β-substituted 3α-hydroxy-5α-(24 examples) and -5β-pregnan-20-ones (7 examples) is evaluated as potent allosteric modulators for the γ-aminobutyric acidA (GABAA) re