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Synthesis and human leukocyte elastase inhibitory activity of novel 2-spiro(2′,2′-diphenylcyclopropane) cephalosporin sulfones

✍ Scribed by Andhe V. Narender Reddy; Charles Y. Fiakpui; David P. Czajkowski; Paul Spevak; Jadwiga Kaleta; Ronald G. Micetich; Samarendra N. Maiti

Publisher
Springer US
Year
1998
Tongue
English
Weight
501 KB
Volume
34
Category
Article
ISSN
0009-3122

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The inhibitory activity toward human leukocyte elastase (HLE), cathepsin G (Cat G), and proteinase 3 (PR 3) of a series of saccharin derivatives having a sulfinate leaving group was investigated. The results of this study revealed that (a) inhibitory activity is dependent on the nature and pKa of th