✦ LIBER ✦

Synthesis and Hill Inhibitory Activity of New Substituted 3-Aryl-5-cyano-6-methylthio Pyrimidine-2, 4-diones

✍ Scribed by Hua-Yin Liu; Fang-Zhong Hu; Hua-Zheng Yang

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 244 KB
Volume: 19
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.20010190414

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✦ Synopsis

Abstract

Novel substituted derivatives of 3‐aryl‐5‐cyano‐6‐methylthiopyrimidine‐2, 4‐diones were synthesized by the reaction of ethyl 2‐cyano‐3,3′‐dimethylthioacrylate with arylureas in good yields. The structures of all title compounds were evaluated by elemental analyses and ^1^H NMR spectra and compound 2c was also confirmed by X‐ray diffraction. Hill reaction inhibitory activity of title compounds was assayed.

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