Synthesis and fungicidal activity of 1,3-thiazoline derivatives bearing nitrophenyl group on the 2-position

✍ Scribed by Qiuying Zhao; Jing Li; Xiaojing Yan; Huizhu Yuan; Zhaohai Qin; Bin Fu

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2011
• Tongue: English
• Weight: 119 KB
• Volume: 48
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.570

✦ Synopsis

Abstract

Ortho‐, meta‐, or para‐nitro benzoic acid were refluxed with excess SOCl~2~ to give acyl chloride, which condensed with β‐amino alcohol in the presence of Et~3~N in dichloromethane to afford β‐hydroxyamide; finally, sulphonation and cyclization were simultaneously conducted to afford 1,3‐thiazoline derivatives. Fungicidal activity of these new thiazolines against eight agrocultural fungi were evaluated, and two of this type of compounds displayed good fungicidal activity comparable or superior to commercial fungicide chlorothalonil against two fungi at a concentration of 50 mg/L. J. Heterocyclic Chem., (2011).