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Synthesis and Functionalization of 6,7-Dihydro-[1,4]dioxino[2,3-d]pyrimidines.

✍ Scribed by Guido Lavecchia; Sabine Berteina-Raboin; Gerald Guillaumet


Publisher
John Wiley and Sons
Year
2007
Weight
22 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract magnified image The condensation of 5‐amino‐4‐phenyl‐1,2,3‐triazole (**1**) with chalcones **2a‐e** or 3‐dimethylamino‐propiophenone (**4f**) leads to the 6,7‐dihydro‐(1,2,3)‐triazolo[1,5‐__a__]pyrimidines **3a‐f.** The equilibrium of **3** and the tautomeric 4,7‐dihydro‐(1,2,3)‐triazo

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## Abstract A general synthetic approach to pyrazolo[4,3‐__d__]pyrimidines is reported. Aldehydes, arylideneanilines, carboxylic acids and orthoesters are used as one‐carbon units for bridging the two amino functions of 4‐amino‐1‐alkyl‐3‐propylpyrazole‐5‐carboxamides.