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Synthesis, and functional properties of a modified human insulin A-Chain: implication in a ‘Mini-Insulin’ structure determination

✍ Scribed by Guillaume Le Flem; François-Yves Dupradeau; Jean-Pierre Pujol; Jean-Pierre Monti; Patrick Bogdanowicz

Book ID
108479205
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
207 KB
Volume
10
Category
Article
ISSN
0968-0896

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✍ Dr. Steen G. Melberg; W. Curtis Johnson Jr. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 629 KB

## Abstract Vacuum UV circular dichroism spectra measured down to 178 nm for hexameric 2‐zinc human insulin, zinc‐free human insulin, and the two engineered and biologically active monomeric mutants, [B/S9D] and [BS9D, T27E] human insulin, show significant differences. The secondary structure analy