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Synthesis and folding preferences of γ-amino acid oligopeptides: stereochemical control in the formation of a reverse turn and a helix

✍ Scribed by Stephen Hanessian; Xuehong Luo; Robert Schaum

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
302 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

The stereoselective synthesis of a-cinnamyl y-amino acids and the corresponding oligopeptides is described. Detailed 1D and 2D NMR studies in pyridine-ds .show that the (0tR)-cinnamyl y-amino acid tetrapeptide adopts a reverse turn structure, while the (otS)-cinnamyl y-amino acid tetrapeptide adopts a right-handed helical structure.

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