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Synthesis and evaluation of β-carboline derivatives as inhibitors of human immunodeficiency virus

✍ Scribed by Keyur G. Brahmbhatt; Nafees Ahmed; Sudeep Sabde; Debashis Mitra; Inder Pal Singh; Kamlesh K. Bhutani

Book ID
104004532
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
196 KB
Volume
20
Category
Article
ISSN
0960-894X

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✦ Synopsis

A series of b-carboline derivatives were synthesized by utilizing aromatization and chemoselective alkylation method recently reported from our laboratory. Synthesized derivatives were evaluated for anti-HIV activity in human CD4+ T cell line (CEM-GFP) infected with HIV-1 NL 4.3 virus. 1-Formyl-b-carboline-3carbxylic acid methyl ester (15) showed inhibition of human immunodeficiency virus at IC 50 = 2.9 lM.

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