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Synthesis and evaluation of α-ketotriazoles and α,β-diketotriazoles as inhibitors of Mycobacterium tuberculosis

✍ Scribed by Menendez, Christophe; Rodriguez, Frédéric; Ribeiro, Ana Luisa de Jesus Lopes; Zara, Francesca; Frongia, Céline; Lobjois, Valérie; Saffon, Nathalie; Pasca, Maria Rosalia; Lherbet, Christian; Baltas, Michel

Book ID
120539053
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
420 KB
Volume
69
Category
Article
ISSN
0223-5234

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## Abstract __Mycobacterium tuberculosis__ ribonucleotide reductase (RNR) is a potential target for new antitubercular drugs. Herein we describe the synthesis and evaluation of peptide inhibitors of RNR derived from the __C__‐terminus of the small subunit of __M. tuberculosis__ RNR. An __N__‐termin