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Synthesis and evaluation of the antitumor activity of 4,5-diamino-substituted 1,2-benzoquinones

✍ Scribed by Huang, Zhen Dong; Chen, Ying Nan; Menon, Krishna; Teicher, Beverly A.


Book ID
126259573
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
671 KB
Volume
36
Category
Article
ISSN
0022-2623

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The 2,5-bisacrylate-substituted 1,4-benzoquinone bisketal 7a was synthesized by electrochemical oxidation of the corresponding dimethoxybenzene 6. The methyl ester 7a was transesterified to the corresponding ethyl, n-propyl and isopropyl esters 7bΟͺ7d by Ti(OEt) 4 catalysis and to the corresponding n