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Synthesis and evaluation of radioiodinated 2-(2(RS)-aminopropyl)-5-iodothiophenes as brain imaging agents

✍ Scribed by Goodman, Mark M.; Kabalka, George W.; Marks, Ronald C.; Knapp, F. F.; Lee, J.; Liang, Y.

Book ID
111869800
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
919 KB
Volume
35
Category
Article
ISSN
0022-2623

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## Abstract A novel series of iodinated indomethacin derivatives was synthesized, and evaluated as selective inhibitors of COX‐2. Two candidate compounds __N__‐(__p__‐iodobenzyl)‐2‐(1‐(__p__‐chlorobenzoyl)‐5‐methoxy‐2‐methyl‐1__H__‐indol‐3‐yl)acetamide (3) and 1‐(__p__‐iodobenzyl)‐5‐methoxy‐2‐methy