Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras
β Scribed by Ronald Wolin; David Wang; Joseph Kelly; Adriano Afonso; Linda James; Paul Kirschmeier; Andrew T McPhail
- Book ID
- 108038943
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 327 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
FriedlΓ€nder condensation of 5-aminopyrazole-4-carbaldehydes 1 with formamide 2a or benzamide 2b gave pyrazolo [3,4-d]pyrimidine derivatives 3. Cyclocondensation of 1 with cyclopentanone, N-benzyl-4piperidone and 6-methoxy-1-tetralone yielded cyclopenta[b]pyrazolo[4,3-e]pyridines 4, pyrazolo[3,4-b]-[