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Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras

✍ Scribed by Ronald Wolin; David Wang; Joseph Kelly; Adriano Afonso; Linda James; Paul Kirschmeier; Andrew T McPhail


Book ID
108038943
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
327 KB
Volume
6
Category
Article
ISSN
0960-894X

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

A convenient route for the synthesis of
✍ Madhukar N. Jachak; Appasaheb B. Avhale; Vijay J. Medhane; Raghunath B. Toche πŸ“‚ Article πŸ“… 2006 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 363 KB

FriedlΓ€nder condensation of 5-aminopyrazole-4-carbaldehydes 1 with formamide 2a or benzamide 2b gave pyrazolo [3,4-d]pyrimidine derivatives 3. Cyclocondensation of 1 with cyclopentanone, N-benzyl-4piperidone and 6-methoxy-1-tetralone yielded cyclopenta[b]pyrazolo[4,3-e]pyridines 4, pyrazolo[3,4-b]-[