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Synthesis and evaluation of pyrazolignans. A new class of cytotoxic agents

✍ Scribed by Marina Gordaliza; JoséM. Miguel del Corral; M. Angeles Castro; M. Luisa López-Vázquez; Arturo San Feliciano; M. Dolores García-Grávalos; Alain Carpy

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
563 KB
Volume
3
Category
Article
ISSN
0968-0896

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✦ Synopsis

A series of fused pyrazole derivatives of cyclolignans have been prepared through simple chemical routes and evaluated for their cytotoxic activities in culture cells of P-388 murine leukemia, A-549 lung carcinoma and HT-29 colon carcinoma. Despite the lack of the lactone moiety in their structures, they show lCs0 values at I~M levels.

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