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Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins

โœ Scribed by Sanaa K. Bardaweel; Brahma Ghosh; Carston R. Wagner

Book ID
113496312
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
214 KB
Volume
22
Category
Article
ISSN
0960-894X

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Histidine triad (HIT) proteins were until recently a superfamily of proteins that shared only sequence motifs. Crystal structures of nucleotide-bound forms of histidine triad nucleotide-binding protein (Hint) demonstrated that the conserved residues in HIT proteins are responsible for their distinct